ABSTRACT
Objective@#To study the effect of radical resection combined with antiviral therapy on hepatitis B virus infection.@*Methods@#From January 2012 to January 2016, 46 patients with hepatocellular carcinoma complicated with hepatitis B virus infection in the First People's Hospital of Jiashan County were enrolled in this study.All the subjects included in this study had complete clinical data and were willing to cooperate with this study.According to the random number table method, the patients were divided into two groups, with 23 cases in each group.The two groups were all treated by radical resection, the control group was not given anti-viral treatment after operation, the study group was given anti-virus combination therapy after surgery.The patients were followed up for more than 1 year.The levels of liver function[alanine aminotransferase (ALT), serum albumin (ALB), prealbumin (PA)]and hepatitis B virus (HBV-DNA) were measured before and after operation in both two groups.The incidence rate of postoperative complications, length of hospital stay, medical expenses and recurrence rate were analyzed.@*Results@#There were no statistically significant differences in ALT, ALB, PA and HBV DNA between the two groups before operation (all P>0.05). There were statistically significant differences between the two groups after operation[ALT: (97.74±33.27)U/L vs.(142.98±53.41)U/L, t=3.447; ALB: (34.57±5.01)g/L vs.(38.44±4.32)g/L, t=2.805; PA: (192.14±53.24)mg/L vs.(159.85±53.96)mg/L, t=2.042; HBV-DNA: (4.25±1.04)logcopes/mL vs.(6.22±1.18)logcopes/mL, t=6.006, all P<0.05]. The incidence rate of postoperative complications, hospitalization time, medical expense of the study group were significantly lower than those of the control group[complications: 8.70% vs.43.45%, χ2=7.215; hospitalization time: (17.43±4.53)d vs.(20.94±5.05)d, t=2.481; medical expenses: (3.28±1.24) million yuan vs.(4.68±1.17) million yuan, t=3.938, all P<0.05]. After follow-up for 1 year, both two groups had recurrence, the difference was not statistically significant between the two groups(P>0.05).@*Conclusion@#Hepatocellular carcinoma with hepatitis B virus infection in patients with radical resection and anti-virus combination therapy, can better improve the patients' liver function and viral indicators, shorten the hospital stay, reduce medical costs, and can reduce the incidence of complications, with high safety.
ABSTRACT
Objective To evaluate the role of serum adenosine deaminase in the diagnosis and treatment of acute,chronic hepatitis.Methods WanFang Data,CNKI and PubMed were retrieved in order to screen literature about the relationship between serum ADA and acute and chronic hepatitis,the retrieval time was from the beginning of the database to December 1st,2016.After evaluating quality of the included studies, the meta-analysis was conducted to analyze the relationship between the level of serum ADA and acute,chronic hepatitis via RevMan 5.2 software.Results A total of 28 articles were identified including 1688 cases with acute hepatitis and 1843 cases with chronic hepatitis.The results of meta-analysis showed that the levels and positive rate of serum ADA were significantly higher in the acute hepatitis groups than that in chronic hepatitis groups(MD=4.13,95%CI(0.43,7.84),P=0.03;OR=1.94,95%CI(1.19,3.14),P=0.007).Funnel plots showed significant publication bias,and may have implications for Meta analysis(P=0.001).Conclusion Heterogeneity of the literatures mainly comes from the clinical heterogeneity and statistical heterogeneity.The serum ADA has certain value in the diagnosis and treatment of acute and chronic hepatitis.